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A growing body of scientific research demonstrates the basis for Whole Body Periodic Acceleration Therapy. The repetitive head-to-foot motion of this therapy (WBPA, also termed pGz) adds a pulse to the circulation with each acceleration and deceleration of the body. These additional smaller pulses, which are superimposed on the natural pulse, promote release of beneficial substances (mediators) from the inner lining of blood vessels (endothelium), a process called pulsatile shear stress. These mediators provide a wide range of health benefits that originate from the subject's own body.

Science supports Whole Body Periodic Acceleration for safe and effective therapy.

  1. Periodic Acceleration (pGz) prior to Whole Body Ischemia Reperfusion Injury Provides Early Cardioprotective Preconditioning
    Adams JA, Wu H, Bassuk J, Et Al Life Science (2010);
  2. "Passive Exercise" using whole body periodic acceleration; Effects on coronary microcirculation
    Fukuda S, Shimada K, Kawasaki T, Kono Y, Jissho S, Taguchi H, Maeda K, Yoshiyama M, Fujita M, Yoshikawa J American Heart Journal (2010); 159:620-6
  3. Periodic acceleration (pGz) acutely increases endothelial and neuronal nitric oxide synthase expression in endomyocardium of normal swine.
    Adams JA, Wu H, Bassuk J, Arias J, Uryash A, Kurlansky P Peptides 30 (2009) 373-377
  4. Whole-body periodic acceleration (pGz) reduces brain damage in a focal ischemia model
    Martínez-Murillo, R., Serrano, J., Fernández, A.P., Martínez,A Neuroscience (2008), doi: 10.1016/j.neuroscience.2008.12.005
  5. Low Amplitude Pulses to the Circulation through Periodic Acceleration (pGz) Induces Endothelial Dependent
    Uryash A, Wu H, Bassuk J, Kurlansky P, Sackner MA, Adams JA J Appl Physiol (March 26, 2009).
  6. In vivo upregulation of nitric oxide synthases in healthy rats
    Wu H, Jin Y, Arias J, Bassuk J, Uryash A, Kurlansky P, Webster K, Adams JA Nitric Oxide 21 (2009), 63-68
  7. Acute effects of "delayed postconditioning" with periodic acceleration after asphyxia induced shock in pigs.
    Adams JA, Bassuk JA, Arias J, Wu H, Jorapur V, Lamas GA, Kurlansky P Pediatric research (2008);64: 533-7
  8. Non-selective cyclooxygenase inhibition before periodic acceleration (pGz) cardiopulmonary resuscitation (CPR) in a porcine model of ventricular fibrillation.
    Bassuk JA, Wu D, Lozano H et al. Resuscitation 2008; 77:250-257
  9. Adrenomedullin is increased by pulsatile shear stress on the vascular endothelium via periodic acceleration (pGz).
    Martinez A, Arias J, Bassuk JA et al. Peptides 2008; 29(1):73-78.
  10. Whole-body periodic acceleration enhances brachial endothelial function.
    Matsumoto T, Fujita M, Tarutani Y et al. Circ J 2008; 72(1):139-143.
  11. Nitric oxide synthase isoform inhabition before whole body ischemia reperfusion in pigs; Vital or Protective?
    Adams JA, Wu D, Bassuk J, Arias J, Lozano H, Kurlansky P, Lamas GA Resuscitation 2007; 74: 516-525
  12. Periodic whole body acceleration: a novel therapy for cardiovascular disease.
    Kohler M, Amann-Vesti BR, Clarenbach CF et al. Vasa 2007; 36:261-266
  13. Different roles of nitric oxide synthase isoforms in cardiopulmonary resuscitation in pigs.
    Wu D, Bassuk J, Arias J et al. Resuscitation 2007; 73(1):144-153
  14. Whole-body periodic acceleration modifies experimental asthma in sheep.
    Abraham WM, Ahmed A, Serebriakov I et al. Am J Respi Crit Care Med 2006; 174:743-752
  15. Endothelium and cardiopulmonary resuscitation.
    Adams JA. Crit Care Med 2006; 34(12 Suppl):S458-S465
  16. Biophysics of cardiopulmonary resuscitation with periodic z-axis acceleration or abdominal compression at aortic resonant frequencies.
    Babbs CF. Resuscitation 2006; 69(3):455-469
  17. Post-resuscitation reperfusion injury: comparison of periodic Gz acceleration versus Thumper CPR.
    Wu D, Bassuk J, Arias J et al. Resuscitation 2006; 70(3):454-462
  18. Periodic acceleration: effects on vasoactive, fibrinolytic, and coagulation factors.
    Adams JA, Bassuk J, Wu D et al. J Appl Physiol 2005; 98(3):1083-1090
  19. Periodic acceleration enhances release of nitric oxide in healthy adults.
    Fujita M, Tambara K, Ikemoto M et al. Int J Angio 2005; 14:11-14
  20. Echocardiographic comparison of cardiopulmonary resuscitation (CPR) using periodic acceleration (pGz) versus chest compression.
    Nava G, Adams JA, Bassuk J et al. Resuscitation 2005; 66(1):91-97
  21. Effect of moderate-intensity exercise, whole-body periodic acceleration, and passive cycling on nitric oxide release into circulation.
    Sackner MA, Gummels E, Adams JA. Chest 2005; 128(4):2794-2803
  22. Nitric oxide is released into circulation with whole-body, periodic acceleration.
    Sackner MA, Gummels E, Adams JA. Chest 2005; 127(1):30-39
  23. Cardiopulmonary resuscitation (CPR) using periodic acceleration (pGz) in an older porcine model of ventricular fibrillation.
    Adams JA, Wu D, Bassuk J et al. Resuscitation 2004; 60(3):327-334
  24. Say NO to fibromyalgia and chronic fatigue syndrome: an alternative and complementary therapy to aerobic exercise.
    Sackner MA, Gummels EM, Adams JA. Med Hypotheses 2004; 63(1):118-123
  25. Survival and normal neurological outcome after CPR with periodic Gz acceleration and vasopressin.
    Adams JA, Bassuk J, Wu D et al. Resuscitation 2003; 56(2):215-221
  26. Effects of periodic body acceleration on the in vivo vasoactive response to N-w-nitro-L-arginine and the in vitro nitric oxide production.
    Adams JA, Moore JE, Jr., Moreno MR et al. Ann Biomed Eng 2003; 31(11):1337-1346
  27. Regional blood flow during periodic acceleration.
    Adams JA, Mangino MJ, Bassuk J et al. Crit Care Med 2001; 29(10):1983-1988
  28. Novel CPR with periodic Gz acceleration.
    Adams JA, Mangino MJ, Bassuk J et al. Resuscitation 2001; 51:55-62
  29. Hemodynamic effects of periodic Gz acceleration in meconium aspiration in pigs.
    Adams JA, Mangino MJ, Bassuk J, Sackner MJ. J Appl Physiol 2000; 89:2447-2452
  30. Noninvasive motion ventilation (NIMV): a novel approach to ventilatory support.
    Adams JA, Mangino MJ, Bassuk J, Inman DM, Sackner MA. J Appl Physiol 2000; 89:2438-2446


September 08, 2010
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